Exploration of Long-Term Potentiation (LTP)-like Pain Amplification and Conditioned Pain Modulation (CPM) on Pain-LTP in Humans

Aalborg Universitet Exploration of Long-Term Potentiation (LTP)-like Pain Amplification and Conditioned Pain Modulation (CPM) on Pain-LTP in Humans

Perceptual correlates of nociceptive long-term potentiation and long-term depression in humans.

Long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength are ubiquitous mechanisms of synaptic plasticity, but their functional relevance in humans remains obscure. Here we report that a long-term increase in perceived pain to electrical test stimuli was induced by high-frequency electrical stimulation (HFS) (5 x 1 sec at 100 Hz) of peptidergic cutaneous afferents (27% a...

Psychophysical Evidence for Long-Term Potentiation of C-Fiber and A -Fiber Pathways in Humans by Analysis of Pain Descriptors

Hansen N, Klein T, Magerl W, and Treed R-D. Psychophysical evidence for long-term potentiation of C-fiber and A -fiber pathways in humans by analysis of pain descriptors. J Neurophysiol 97: 2559 –2563, 2007. First published January 10, 2007; doi:10.1152/jn.01125.2006. Long-term potentiation of human pain perception (nociceptive LTP) to single electrical test stimuli was induced by high-frequenc...

Psychophysical evidence for long-term potentiation of C-fiber and Adelta-fiber pathways in humans by analysis of pain descriptors.

Long-term potentiation of human pain perception (nociceptive LTP) to single electrical test stimuli was induced by high-frequency stimulation (HFS) of cutaneous nociceptive afferents. Numerical pain ratings and a list of sensory pain descriptors disclosed the same magnitude of nociceptive LTP (23% increase for >60 min, P < 0.001), whereas affective pain descriptors were not significantly enhanc...

Test-Retest Reliability of 10 Hz Conditioning Electrical Stimulation Inducing Long-Term Potentiation (LTP)-Like Pain Amplification in Humans

BACKGROUND 10 Hz conditioning electrical stimulation (CES) has been shown to induce long-term potentiation (LTP)-like pain amplification similar to traditional 100 Hz CES in healthy humans. The aim of this study was to assess the test-retest reliability and to estimate sample sizes required for future crossover and parallel study designs. METHODS The 10 Hz paradigm (500 rectangular pulses las...